Imagine turning back the clock on your body’s cells! That’s what Dr. David Sinclair and his student, Yuancheng Ryan Lu, started working on ten years ago. They teamed up and began exploring something called “cellular reprogramming” using special genes called OSK (Oct4, Sox2, and Klf4) therapy. What was once just a wild idea is now one of the most exciting ways we’re trying to fight chronological aging. The scientific foundation of this endeavor rests on Yuancheng Ryan Lu’s seminal discovery: that the OSK gene combination possesses the unique capacity to safely reverse epigenetic aging. The fact behind this is that epigenetic marks—chemical tags on DNA and proteins—change with age, affecting gene expression without altering the underlying DNA sequence. OSK genes have been shown to ‘reset’ these marks, effectively reprogramming cells to a younger state. Furthermore, preclinical animal models have provided compelling evidence that this epigenetic reprogramming can not only halt but potentially cure age-related diseases, including severe conditions like blindness. When they first talked about “reversing aging,” some scientists thought they were crazy. Now, in January 2026, something truly big is happening: the OSK life extension treatment is going to be tested in people for the very first time! This is a massive step forward in medicine. These tests will help us understand if OSK is safe for humans and if it can really make old body parts work like they used to.
Even though some people and traditional media outlets called their ideas “controversial” at first, the science has kept getting stronger and stronger. This moment isn’t just important for the scientists; it’s a huge turning point for everyone’s future, showing how we might be able to deal with aging in completely new ways.
Today (the 17th June 2025) the announcement is found in the details of this reels post on David Sinclair’s Facebook page. https://www.facebook.com/reel/1040964591444599
